Answers about 7‑OH, kratom, and real help to quit

Get clear information on 7-OH and kratom, including effects, withdrawal, bans, and treatment options. Learn more below, or book a visit to talk to a clinician today.

Latest updates

• MGM-15, MGM-16, & mitragynine pseudoindoxyl Schedule I Aug 26
• HHS reopens 7-OH threshold comment period through 9/10 Aug 26
• Original public comment period on 7-OH threshold closes Jul 31
• Congressional Research Service publishing brief on scheduling Jul 17
• DEA files notices of intent in the Federal Register Jul 6

A federal ban involving synthetic 7-OH is currently pending and could take effect at any time.

What to know about 7-OH and kratom

Clear answers about what 7-OH and kratom are, how they affect the body, and what to know about dependence and withdrawal.

What is 7-OH?

7-OH, short for 7-hydroxymitragynine, is a compound found naturally in small amounts in the kratom plant. It can also be found in concentrated products such as tablets, gummies, and drink shots, which may contain much higher amounts of 7-OH than occur naturally in kratom leaves. 7-OH acts on opioid receptors in the brain. Because concentrated 7-OH products can deliver much more of the compound at once, regular use can lead to tolerance and physical dependence. That means you may need more over time to get the same effect, and you may experience withdrawal symptoms if you cut back or stop.

What is kratom?

Kratom comes from the leaves of a tree native to Southeast Asia, where it has traditionally been chewed or brewed as tea. In the U.S., it’s commonly sold as a powder, capsule, tea, or extract. It contains several naturally occurring compounds, including mitragynine and small amounts of 7-OH, that interact with opioid receptors in the brain. Its effects can vary depending on the amount used, the product, and the person. People commonly report more stimulating effects at lower amounts and more calming or sedating effects at higher amounts. Regular kratom use can lead to tolerance and physical dependence, which means stopping or reducing use may cause withdrawal symptoms.

The dangers of 7-OH & kratom

Concentrated 7-OH products often contain much higher levels of 7-OH than are naturally found in kratom leaf. This can make it easier to develop dependence and may lead to more severe withdrawal symptoms. It can also be hard to know exactly how strong a product is or what’s in it. The amount of 7-OH and other ingredients can vary from one tablet, gummy, shot, or extract to another, and the label may not always tell the full story. Mixing 7-OH or kratom with alcohol, benzodiazepines, opioids, or other substances that slow your central nervous system can be especially dangerous. Taking them together can increase the risk of serious complications, including dangerously slowed breathing.

7-OH withdrawal symptoms

If you’ve been using 7-OH or kratom regularly, cutting back or stopping can cause withdrawal as your body adjusts. You may experience anxiety or irritability, muscle aches, sweating or chills, nausea, diarrhea, trouble sleeping, restlessness, and strong cravings. When symptoms start and how intense they feel can vary depending on what you’ve been taking, how much and how often you use it, and how long you’ve been using it. Withdrawal from concentrated 7-OH may come on sooner and feel more intense than withdrawal from traditional kratom because these products can contain much higher concentrations of 7-OH.

Read more about 7-OH, kratom, and your options

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How to quit 7-OH and start feeling like yourself again

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7-OH and kratom ban update Aug 2026: where it’s legal vs. banned

If you’re using kratom or considering it, you’ve probably wondered: Is this… August 26, 2026

Kratom and 7-OH: differences, effects, and treatment options

Kratom is a plant-based substance that’s easy to find online, in stores… July 15, 2026

7-OH effects: What 7-hydroxymitragynine does to your brain and body

7-OH affects your brain the same way other opioids do, just more… August 13, 2026

Get help quitting 7-OH or kratom

Meet with a licensed clinician online

With 7-OH and kratom bans and restrictions changing across the country, many patients are wondering how to quit, whether tapering is an option, and what treatment may be right for them. Meet with a QuickMD clinician by video or phone to understand what to expect, manage withdrawal symptoms, and discuss your options.

QuickMD patients can also get additional support through one-on-one counseling, and depending on where you live, you may also have access to free peer support groups.

How to use this information

The information on this page is meant to help you better understand 7-OH and kratom and prepare for conversations about your care. It isn’t a substitute for medical advice from a licensed clinician. Laws and regulations can also change quickly and vary by state. Use the legal information on this page as a starting point, and check the linked sources for the most current information.