Sertraline (generic Zoloft®)

Just $19 for a 30-day supply Free 2-day shipping No insurance required

Sertraline is a prescription antidepressant commonly used to treat depression, anxiety, and related mental health conditions. It can help improve mood, reduce anxiety, ease panic attacks, and restore motivation.

• Get care from a real doctor, without leaving home
• Same-day prescriptions available
• Medication delivered free, straight to your door

Book a visit to meet with a QuickMD doctor for a sertraline prescription or refill

A QuickMD doctor can prescribe medication only after your visit, and prescriptions aren't guaranteed. The listed price covers medication only and doesn't include the cost of your doctor visit.

You deserve to feel good every day

Get sertraline prescribed online from the comfort of home. $99 visit fee—no insurance required.

Getting started with sertraline at QuickMD

Description

Sertraline is an FDA-approved SSRI (selective serotonin reuptake inhibitor), or a type of antidepressant used to treat depression and anxiety, including generalized anxiety disorder (GAD), social anxiety, and panic disorder. It can help stabilize mood, reduce feelings of fear, nervousness, and worry. When prescribed appropriately, patients may also notice improvements in sleep and energy.

• How to use

Take sertraline by mouth with a glass of water, once a day, at the same time each day, or as directed by your QuickMD doctor. You may take it with or without food. If you experience stomach upset, take it with food to help reduce nausea. Always use this medication exactly as prescribed by your doctor. Staying on schedule helps your body maintain consistent levels of the medication, which makes the treatment more effective. Each prescription comes with a patient information leaflet. Be sure to read it carefully, and ask your doctor if you have any questions.

• Benefits

Sertraline may provide the following benefits:

• Improved mood and a greater sense of emotional stability
  • Reduced feelings of anxiety and fear
  • Fewer and less intense panic attacks
  • Restored interest and motivation in daily activities
  • Better sleep quality and increased energy levels
  • Long-term effectiveness
  • Well-established safety record

Benefits and treatment outcomes vary from person to person.

• Side effects

Serious or adverse side effects from sertraline are rare. However, some patients may experience:

• Nausea
  • Dry mouth
  • Increased sweating
  • Trouble sleeping
  • Mild tremors (shakiness)
  • Changes in weight
  • Reduced sex drive
  • Restlessness

Contact your doctor right away if you experience signs of serotonin syndrome (a rare but serious reaction that can include rapid heart rate, confusion, and muscle twitching), unusual bleeding, or worsening depression.

This is not a full list of side effects, interactions, or warnings, and it should not replace medical advice. For guidance tailored to your health and medications, always talk with your healthcare provider or pharmacist.

• Safety information

Sertraline must be prescribed by a licensed doctor. Like any medication, sertraline comes with important safety considerations, including possible side effects, serious risks, and certain conditions where it may not be safe to use. A consultation with a QuickMD doctor is required to review your health and determine if this prescription medication is appropriate for you.

Sertraline may not be appropriate if you:

• Are taking or have recently taken an MAO inhibitor (such as phenelzine, selegiline, or linezolid)
  • Are taking pimozide
  • Have a known allergy or hypersensitivity to sertraline
  • Are taking disulfiram (applies to the oral concentrate form only)
  • Are in the first trimester of pregnancy or breastfeeding, without first discussing risks with your doctor

This is not a complete list of precautions, contraindications, or drug interactions. Always talk with your healthcare provider or pharmacist about your medical history and any medications or supplements you are taking before starting sertraline.

Sertraline (Zoloft®)

$19/30-day supply

Start feeling better mentally and emotionally. Meet with a QuickMD doctor and, if appropriate, receive a prescription for sertraline. No insurance required.

• Support your mental health with proven treatment
• Same-day prescriptions available after your visit
• Delivered straight to your door when prescribed

Frequently asked questions

How much is sertraline without insurance?

Sertraline tablets are $19 with QuickMD’s cash-pay option, giving you clear, upfront pricing with no hidden fees. Prescriptions are filled through QuickMD Home Delivery and shipped right to your door.

How long does it take for sertraline to work?

Patients may begin to notice early improvements, particularly in sleep, energy, and appetite, within the first one to two weeks. The full antidepressant and anti-anxiety effects may take four to six weeks to develop. It’s important to keep taking sertraline as prescribed during this period, even if you don’t feel a difference right away. You will follow up with your QuickMD doctor to track your progress and adjust your dose if needed.

What should I avoid while taking sertraline (Zoloft)?

Avoid alcohol while taking sertraline, as it can increase the risk of side effects like dizziness and drowsiness. Do not take sertraline with MAOIs (monoamine oxidase inhibitors—a separate class of antidepressants that includes medications like Nardil and Parnate). Use caution with NSAIDs like ibuprofen and aspirin, as these can raise your bleeding risk. Always let your doctor know about any other medications, vitamins, or supplements you’re taking before beginning treatment.

Start treatment with sertraline online

Book your first visit

Getting started begins with a simple online visit. You'll meet with a licensed QuickMD doctor from the comfort of home, where you can talk openly about what you've been going through and what kind of support you're looking for. The process is designed to feel comfortable, supportive, and pressure-free, so you can move forward with a clear understanding of what to expect and what comes next.

Learn more about sertraline

Your doctor will take time to understand any challenges you're facing, your mental health history, and what you've tried so far. If sertraline is appropriate, they'll guide you through how it works in your body, how to take it, what to expect, and how it can help you stabilize your mood, reduce anxiety, and restore your interest in daily life. You'll leave your visit feeling informed and confident in your next steps.

Get your medication delivered

If your doctor prescribes sertraline, your prescription is sent directly to our pharmacy partner and shipped straight to your door. You'll receive clear instructions on how to take it, and your care doesn't stop there. Follow-up visits give your doctor a chance to check in on how you're responding, adjust your dose if needed, and make sure you're getting the support and relief you need.